Yao Xuebiao (姚雪彪)
Professor Yao Xuebiao researches centromere dynamics, chromosome segregation and membraneless cellular structures.
At a glance
Yao Xuebiao (姚雪彪)
Professor Yao Xuebiao researches centromere dynamics, chromosome segregation and membraneless cellular structures.
Research location: Biology Building, West Campus.
Research contributions and academic biography
Yao Xuebiao (姚雪彪) | Research contributions and academic biography
Yao Xuebiao's research concerns cell organization, chromosome segregation and the dynamics of biological structures without surrounding membranes. Chromosomes must be distributed reliably during cell division, while membraneless organelles illustrate how cells organize materials through dynamic molecular interactions. These topics bring together cell imaging, molecular biology and mechanistic questions about living systems. His research is associated with USTC's biomedical research community and the Biology Building on West Campus.
Chromosome segregation and centromere biology
Yao Xuebiao’s cell-biology work investigates mechanisms that preserve genetic stability during cell division. Centromeres, mitotic spindles and proteins associated with chromosome segregation are recurring topics.
Research on membraneless organelles adds questions about how cellular components organize without surrounding membranes. His scholarly background includes doctoral work at UC Berkeley and later research training at UC San Diego.
Academic profile and research
Cell biology, chromosome inheritance and centromere dynamics
Research focus
Professor Yao Xuebiao studies how dividing cells preserve chromosome stability and transmit genetic information. His laboratory examines the molecular organization of the centromere, dynamic assemblies without membranes and the functions of the mitotic spindle. These questions connect the basic cell biology of division with the molecular mechanisms that shape tissue renewal.
Academic background
He completed a PhD in cell and molecular biology at the University of California, Berkeley in 1995, followed by postdoctoral research at the University of California, San Diego. USTC describes his work on centromere proteins, chromosome dynamics and cellular quality control. His collaborative research also includes organoid models that reveal how modifications to the spindle-associated protein EB1 affect spindle positioning during mitosis.
Research contributions
A 2021 USTC news report describes a collaborative Nature Chemical Biology study of TIP60-mediated EB1 crotonylation and spindle positioning. In early 2026, USTC reported that he helped lead a national major research initiative examining cell-cluster formation and regulation. These examples situate his laboratory at the intersection of cell biology, quantitative imaging and chemical biology.